Are GLP-1 medications not the right fit for your weight loss journey? Whether due to contraindications, severe side effects, or a desire for quicker results, alternative medications can offer effective solutions. Here's a guide to some common medications used for weight loss, beyond GLP-1 agonists like Ozempic, Wegovy, Zepbound, Mounjaro, and Saxenda.
Understanding GLP-1 Agonists:
Before diving into alternatives, it's important to remember how GLP-1 agonists, such as semaglutide or tirzepatide, work. These medications change the hormones in the stomach and intestines, slowing food digestion and reducing appetite.
1. Phentermine:
An enduring solution, Phentermine, an oral daily medication present for over 60 years, swiftly controls appetite by reducing hunger sensations in the brain. Well-tolerated with minimal side effects, it offers long-term weight loss similar to GLP-1 agonists. Precautions are necessary for those with heart conditions. It’s approved for individuals over 16 and need to be avoided during pregnancy and in older individuals).
2. Qsymia:
Introduced in 2012, Qsymia combines phentermine and topiramate, working synergistically at lower doses for effective appetite suppression. With four possible doses titrated over two months, it's well-tolerated and suitable for weight loss in children twelve years and older (not for pregnant individuals). Weight loss effects are similar to GLP-1 agonists.
3. Contrave:
Approved in 2014, Contrave combines Wellbutrin and Naltrexone for daily appetite and cravings control. While slightly less effective for weight loss than some alternatives, it enhances mood and energy. Not recommended for children under 18.
4. Xenical:
Taken with meals, Xenical blocks fat absorption and is particularly useful for those unable to take appetite suppressants or with minimal hunger struggles. Safe and approved for children starting at age 12, it works gradually over months rather than immediately. It can potentially cause oily stools with high-fat diets.
5. Metformin:
Frequently used for diabetes treatment, Metformin is safe for adults and children. It aids in weight loss and insulin resistance, and provides a feeling of fullness. While its weight loss benefits are modest, it's a good starting point for those managing sugar and diseases such as PCOS.
6. Plenity:
Approved in 2019 as a "medical device," Plenity capsules operate like super-fiber. Taken before eating, it expands in the stomach, curbing appetite and preventing the consumption of large portions. Like fiber, it passes through the gut later in the day. Plenity is safe but not as potent as some options mentioned above.
Others:
Beyond these, there are several less frequently used medications that can be employed in special situations or combinations.
8. Vyvanse:
Used for binge-eating disorder and for individuals with impulsive eating, as seen in Attention Deficit Disorder.
9. Jardiance:
Utilized in diabetes, Jardiance can be helpful with weight loss.
10. Topamax:
Applied in night eating disorder and for anxious eating before sleep.
11. Tenuate:
Similar to Phentermine but shorter-acting, Tenuate can be taken before expected events with plentiful food.
When considering weight management beyond GLP-1 agonists, expert guidance and medical supervision are crucial. At Weight MD, our professionals are here to tailor a plan that suits your unique requirements. Let's embark on your weight loss journey together, exploring the myriad options available for a healthier, happier you.
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